Nanotechnology Center for Mechanics in Regenerative Medicine

2008

Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R.

Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.

Cell 2008 133(4), 666-680.

Shen K, Thomas VK, Dustin ML, Kam L.

Micropatterning of costimulatory ligands enhances CD4+ T cell function.

PNAS 2008 105(22), 7791-7796.

Antia M, Baneyx G, Kubow KE, Young G, Vogel V.

Fibronectin in aging extracellular matrix fibrils is increasingly unfolded by cells and elicits an enhanced rigidity response.

Faraday Discussions 2008 139 (in press).

Hytönen VP, Vogel V.

How force might activate talin’s vinculin binding sites: SMD reveals a structural mechanism.

PLoS Computational Biol 2008 4(2):e24.

Jungbauer, S., H. Gao, J.P. Spatz, and R. Kemkemer.

Two characteristic regimes in frequency dependent dynamic reorientation of fibroblasts on cyclically stretched substrates.

Biophys J 2008 (in press).

Little W, Smith ML, Ebneter U, Vogel V.

Assay to mechanically tune and optically probe fibrillar fibronectin conformations from fully relaxed to breakage.

Matrix Biol. 2008 27(5), 451-461 .

Tsai J, Sun E, Gao Y, Hone JC, Kam LC.

Non-brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers.

Nano Letters 2008 8, 425-430.

2007

Blummel J, Perschmann N, Aydin D, Drinjakovic J, Surrey T, Lopez-Garcia M, Kessler H, Spatz J.P.

Protein repellent properties of covalently attached PEG coatings on nanostructured SiO2-based interfaces.

Biomaterials 2007 28, 4739-4747.

Cavalcanti-Adam EA, Volberg T, Micoulet A, Kessler H, Geiger B, Spatz J.
Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands.
Biophysical J. 2007 92(8), 2964-2974.

Giannone G, Dubin-Thaler B, Rossier O, Cai Y, Chaga O, Jiang G, Beaver W, Doebereiner HG, Freund Y, Borisy G, Sheetz MP.

Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation.
Cell 2007 128, 561-575.

Sims T, Soos T, Xenias H, Dubin-Thaler B, Hofman J, Waite J, Cameron T, Thomas VK, Varma R, Wiggins C, Sheetz MP, Littman D, Dustin ML.
Opposing Effects of PKCq and WASP on Symmetry Breaking and Relocation of the Immunological Synapse.
Cell 2007 129, 773-785.

Smith ML, Gourdon D, Little WC, Kubow KE, Eguiluz RA, Luna-Morris S, Vogel V.
Force-induced unfolding of fibronectin in the extracellular matrix of living cells.
PLoS Biology 2007 5(10), e268.

Storrie H, Guler M, Abu-Amara S, Volberg T, Rao M, Geiger B, Stupp S.
Supramolecular crafting of cell adhesion.
Biomaterials 2007 28(31), 4608-4618

Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B.
Functional atlas of the integrin adhesome.
Nature Cell Biology 2007 9(8), 858-867.

2006

Cai Y, Biais N, Giannone G, Tanase M, Ladoux B, Hofman J, Wiggins CH, Sheetz MP.
Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow.
Biophysical J. 2006 91(10), 3907-3920

Doebereiner HG, Dubin-Thaler BJ, Hofman JM, Xenias HS, Sims TN, Giannone G, Dustin MI, Wiggins C, Sheetz MP.
Lateral membrane waves constitute a universal dynamic pattern of motile cells.
Physical Review Letters. 2006 97(3):038102.

Sawada Y, Tamada M, Dubin-Thaler B, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP.
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas.
Cell 2006 127, 1015-1026.

Vogel V, Sheetz MP.
Local force and geometry sensing regulate cell functions.
Nature Review Molecular Cell Biology. 2006 7(4), 265-275.

Dunlop, I., M.L. Dustin and J.P. Spatz. 2008. Artificial biomimetic substrates in the study of the immunological synapse.

In Nanotechnology (Major Reference Work).

Editors: H. Fuchs, M. Grätzel, H. Krug, G. Schmid, V. Vogel, and R. Waser, Wiley-VCH Verlag GmbH & Co, Germany. (in press).

Hytönen, V.P., M.L. Smith, and V. Vogel. 2008. Translating mechanical force into discrete biochemical signal changes: multimodularity imposes unique properties to mechanotransductive proteins.

In Mechanotransduction.

Editor: Mohammad Mofrad. (in press).

Vogel, V., and M. P. Sheetz. 2008.

A Matter of Force in Health and Disease: engineering cell and tissue functions by controlling mechanical aspects.

In Nanomedicine.

Editor: Viola Vogel, Wiley. (in press).

Tanase, M., N. Biais, and M. P. Sheetz. 2007. Magnetic tweezers in Cell Biology.

In Methods in Cell Biology.

Editors: D. Discher, and Y. L. Wang, AP.

Engler AJ, Sen S, Sweeney HL, Discher DE.
Matrix elasticity directs stem cell lineage specification.
Cell. 2006;126(4):677-689.

Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE.
Geometric control of cell life and death.
Science. 1997;276(5317):1425-1428.

Sawada Y, Sheetz MP.
Force Transduction by Triton Cytoskeletons.
J. Cell Biol. 2002;156:609-615.

Choquet D, DP Felsenfeld, MP Sheetz.
Extracellular matrix rigidity causes strengthening of integrin-cytoskeletal linkages.
Cell. 1997;88:39-48.

Kam L, Boxer SG.
Cell adhesion to protein-micropatterned supported lipid bilayer membranes.
J Biomed Mater Res. 2001;55:487-495.

Calvacanti-Adam EA, Micoulet A, Blçmmel J, Auernheimer J, Kessler H, Spatz JP.
Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly.
Eur J Cell Biol. 2006;85:219-224. Pubmed Link

Cherniavskaya O, Chen C, Heller E, Sun E, Provezano J, Kam L, Hone J, Sheetz MP, Wind SJ.
Fabrication and surface chemistry of nanoscale bioarrays for the study of cytoskeletal protein binding interactions and their effect on cell motility.
J Vac Sci Technol. 2005;B23:2972.

Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R.
Formation of regulatory patterns during signal propagation in a mammalian cellular network.
Science. 2005;309(5737):1078-1083.

Balaban NQ, Schwartz US, Riveline D, Goichberg P, Tzur G, Sabanay I, Mahalu D, Safran S, Bershadsky A, Addadi L, Geiger B.
Force at single focal adhesions determines their assembly: a study using elastic micro-patterned substrates.
Nat Cell Biol. 2001;3: 466-472.

Bershadsky AD, Balaban NQ, Geiger B.
Adhesion-dependent cell mechanosensitivity.
Annu Rev Cell Dev Biol. 2003;19:677-695.

Zaidel-Bar R, Ballestrem C, Kam Z, Geiger B.
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.
J Cell Sci. 2003;116(22):4605-4613. Pubmed Link

Mossman KD, Campi G, Groves JT, Dustin ML.
Altered TCR signaling from geometrically repatterned immunological synapses.
Science. 2005;310:1191-1193.

Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML.
The immunological synapse: a molecular machine controlling T cell activation.
Science. 1999;285:221-227.

Campi G, Varma R, Dustin ML.
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.
J Exp Med. 2005;202:1031-1036.

Vogel V.
Mechanotransduction involving multimodular proteins: converting force into biochemical signals.
Annu Rev Biophys Biomol Struct. 2006;35:459-488.

Thomas WE, Forero M, Yakovenko O, Nilsson L, Vicini P, Sokurenko E, Vogel V.
Catch bond model derived from allostery explains force-activated bacterial adhesion.
Biophys J. 2005;90:753-764. Pubmed Link

Puklin-Faucher E, Gao M, Schulten K, Vogel V.
How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation.
J Cell Biol.
2006;175(2):349-360.

Published Papers from the Nanotechnology Center

Published Papers of Mechanical Biology Studies